A2093
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A2093
Sigma
Aspirin
meets USP testing specifications
| Synonym: | 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, Acetylsalicylic acid, ASA, Aspirin |
| CAS Number: | 50-78-2 |
| Linear Formula: | 2-(CH3CO2)C6H4CO2H |
| Molecular Weight: | 180.16 |
| Beilstein Registry Number: | 779271 |
| EC Number: | 200-064-1 |
| MDL number: | MFCD00002430 |
| PubChem Substance ID: | 24890623 |
Description
| Features and Benefits | Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors. |
Properties
| mp | 134-136 °C(lit.) |
| suitability | meets USP testing specifications |
| Gene Information | human ... ITGA2B(3674), PTGS1(5742), PTGS2(5743) |
Safety
| Personal Protective Equipment | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 1 |
| RTECS | VO0700000 |
| Flash Point(F) | 482 °F |
| Flash Point(C) | 250 °C |
References
| reference | Gilroy, D. W., Differential effects of inhibition of isoforms of cyclooxygenase (COX-1 and COX-2) in chronic inflammation. Inflamm. Res. 47, 79, (1998) |
| Gilroy, D. W., et al., Differential effects of inhibitors of cyclooxygenase (COX-1 and COX-2) in acute inflammation. Eur. J. Pharmacol. 355, 211-217, (1998) | |
| Schror, K., Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis. Semin. Thromb. Hemost. 23, 349-356, (1997) | |
| Shiff, S.J., et al., Cyclooxygenase inhibitors: drugs for cancer prevention. Curr. Opin. Pharmacol. 3, 352-361, (2003) | |
| Merck | Merck 13,856 |
| Beilstein | Beil. 10,IV,138 |
| Aldrich MSDS 1, 26:B / Corp MSDS 1 (1), 48:C / FT-IR 1 (2), 315:D / FT-IR 2 (2), 2887:B / FT-NMR 1 (2), 1293:B / IR-Spectra (2), 909:F / IR-Spectra (3), 1040:A / NMR-Reference 2 (2), 303:D / RegBook 1 (2), 1929:K / Sax 6, 88 / Sigma FT-IR 1 (1), 610:B / Structure Index 1, 310:C:4 |
